En qué consiste la excelencia del hombre y cómo se la logra es el tema de los sofistas. En cuanto a lo primero, la excelencia se mide por el éxito en la actuación pública, en el ámbito de la Polis. En cuanto a lo segundo, en el conocimiento y hábil manejo de las técnicas del discurso. Excelente será pues el hombre que en las conversaciones privadas, en la actuación en el foro o en las asambleas sea capaz de persuadir, y (...) con ello, de hacerse valer. El peligro uso de las técnicas del discurso persuasivo a fin de lograr sus propósitos consiste en quererlo hacer a cualquier costo. La reacción de Sócrates será explicable en tanto se tenga en cuenta su preocupación para subordinar la técnica del discurso a la ética, es decir, a la finalidad última de la palabra sin lo cual la excelencia del hombre poseedor del logos es puramente aparente. (shrink)

Se trata de mostrar que la“hermenéutica del testimonio” deRicoeur, a pesar de darle la dimensiónde la contingencia histórica que le faltaal concepto de “mundo del texto” y deintroducir la mediación histórica de laconciencia, no rompe con loslineamientos kantianos desde loscuales Ricoeur ha concebido suhermenéutica filosófica, ya que eltestimonio es pensado desde la relaciónkantiana entre las ideas y supresentación sensible.This paper intends to show that in spiteof the fact that Ricoeur’s “Hermeneuticsof Testimony” provides the historic dimension that is missing in the (...) conceptof “world of text” and introduces thehistoric conditioning of consciousness, inno way interrupts connection with the Kantian influence within which Ricoeur conceives his philosophical hermeneutics,since the notion of Testimony has been thought from the point of view of the Kantian relation between ideas and their perceptible presentation. (shrink)

Osteopotin is a secreted glycosylated phosphoprotein found in bone and other normal and malignant tissues. Osteopontin can be autophosphorylated on tyrosine residues and can also be phosphorylated on serine and threonine residues by several protein kinases. Autophosphorylation of osteopontin may generate sites for specific interactions with other proteins on the cell surface and/or within the extracelluar matrix. These interactions of osteopontin are thought to be essential for bone mineralization and function. The polyaspartic acid motif of osteopontin, in combination with neighboring (...) sequences that include serine residues phosphorylated by protein kinases, could fold and assemble into a molecular structure that participates in the mineralization of the bone matrix. (shrink)

Transient changes in DNA torsional tension are generated by environmental stimuli and transcriptional activity. In eukaryotic cells, these changes can only be accommodated by a chromatin structure that is flexible. This property of chromatin may be essential to the regulation of eukaryotic gene activity.

Metal ions may play an essential role in chromatin organization and, thus, be main actors in the gene expression drama. A model is proposed here for the interaction of DNA‐binding transcriptional regulatory proteins with histone H3 via coordinated metal ions and discussed in relation to the conversion of nucleosomal ‘closed’ to ‘open’ states.

The eukaryotic nucleosome, the basic unit of chromatin, is thermodynamically stable and plays critical roles in the cell, including the maintenance of DNA topology and regulation of gene expression. At its C2 axis of symmetry, the nucleosome exhibits a domain that can coordinate divalent metal ions. This article discusses the roles of the metal‐binding domain in the nucleosome structure, function, and evolution.

The state of debates around the topic of `populism' has made clear the difficulties that exist to provide a coherent definition of the concept. There is much to be argued from historical, epistemological, comparative and sociological perspectives that may provide clarity to the uses of the term. As the world meets new scenarios of uncommon styles of doing politics and the themes of ideological polarization and social segregation take hold, the question about the value of `populism' as a theoretical tool (...) needs to be met with an affirmative stance that delineates its principal characteristics. The present text introduces the reader to four new perspectives that serve such a purpose and locates them among the relevant contemporary literature. (shrink)

This article offers a brief critical summary of our Populism(s) project to date, and introduces Thesis Eleven readers to the articles edited in this Special Issue. We comment on significant recent developments on populism scholarship, and reflect about the most recent developments currently taking place and their (potential) impact on current populism research.

The purpose of this study was to analyze the attitude of a group of cardiologists on the ethical conducts they would accept or adopt when encountered with different hypothetical situations of medical practice. Between August and September of 2011, 700 Argentine cardiologists were surveyed in situations which posed ethical dilemmas in the patient-physician relationship, among colleagues or involving financial agreements with employers or the pharmaceutical industry. Ethical conflicts were evidenced in a series of inappropriate conducts such as differential fees, trips (...) and meals sponsored by laboratories, splitting fees, overbilling, self-referral, charging for patient referral, financial compensation for ordering medical procedures, and various situations derived from the relationship with employers. In general, financial compensation from the pharmaceutical industry was more accepted than the conflictive situations which directly involved patients, colleagues or employers. The rejection of these conducts, the physicians' deontological education and the improvement of financial and organizational conditions in medical practice will help to encourage better medical professionalism and avoid unseemly behaviors. (shrink)

Purpose: To determine the relative value that patients place on consent for procedures in the emergency department (ED) and to define a set of procedures that fall in the realm of implied consent. Methods: A questionnaire was administered to a convenience sample 134 of 174 patients who were seen in the ED of a Midwestern teaching hospital. The questionnaire asked how much time they believed was necessary to give consent for various procedures. Procedures ranged from simple (venipuncture) to complex (procedural (...) sedation). Results: Participants valued a simple blood draw at a low mean of 1.02 minutes of extra time and a lumbar puncture at a high mean of 7.78 minutes. Of all participants 52% and 48% noted a time-value of ?0? time on blood draw and intravenous line starts, respectively, indicating that they desire no additional consent for these procedures. Conclusion: Defining a set of ED procedures covered under implied consent will be difficult because many patients value formal consent for even the simplest procedure. (shrink)

A great variety of medical conditions are subject to the placebo effect. Although there is mounting evidence to suggest that the placebo effect is related to the expectation of clinical benefit, little is still known about the biochemical bases underlying placebo responses. Positron emission tomography studies have recently shown that the placebo effect in Parkinson’s disease, pain, and depression is related to the activation of the limbic circuitry. The observation that placebo administration induces the release of dopamine in the ventral (...) striatum of patients with Parkinson’s disease suggests a link between the placebo effect and reward mechanisms. In addition to Parkinson’s disease, the placebo-reward model may also apply to other disorders. However, the relative contribution of the different neurotransmitters and neuropeptides that are known to be involved in modulating the activity of the limbic system may be disease-specific. Thus, while the placebo-induced clinical benefit observed in Parkinson’s disease would mostly reflect the release of dopamine in the dorsal striatum, the activation of opioid and serotonin pathways could be particularly implicated in mediating placebo responses encountered in pain and depression, respectively. (shrink)

En el texto se presenta a la sofística como precursora de la filosofía práctica, y se la reconoce como anticipadora del pensamiento aristotélico. La vía por la que se muestra dicha relación es el reconocimiento del papel primordial que esta concede al lenguaje y en especial al que adquiere la forma de discursos que buscan persuadir, a la retórica como piedra angular de la formación ciudadana en cuanto preparación para la vida pública. De esta manera se reconoce la importancia que (...) la retórica tuvo para la filosofía en sus orígenes, y cómo perfilaba otra manera de entender la racionalidad, no como teórica sino como práctica. Después se pasa a mostrar cómo según Chaïm Perelman, a partir de una reinterpretación de cierta parte de la obra de Aristóteles, es plausible postular a la retórica como un modelo más adecuado para entender la filosofía. (shrink)

The year 1992 is a year for reflection, because whether or not the quincentenary celebration of the arrival of the Europeans to this continent seems justified, one cannot escape thinking about the impact of this event on our land.As archeology is my area of study, my reflections are directed toward the changes that came about in the relationship between man and animals after 1492, specifically toward what occurred in Mexico once the Spaniards established themselves in this territory.

This chapter argues that from a particularly weak recombination principle and plausible assumptions about the nature of parthood and location, it follows that it is possible that the mereological structure of the material world and that of space-time fail to correspond to one another in very radical ways. The chapter suggests, moreover, that rejecting the possibility of such failures of correspondence leaves us with a choice of no less unappealing alternatives. It also discusses a few ways in which their possibility (...) is relevant to various important debates in metaphysics. (shrink)

One of the key problems the field of Machine Consciousness is currently facing is the need to accurately assess the potential level of consciousness that an artificial agent might develop. This paper presents a novel artificial consciousness scale designed to provide a pragmatic and intuitive reference in the evaluation of MC implementations. The version of ConsScale described in this work provides a comprehensive evaluation mechanism which enables the estimation of the potential degree of consciousness of most of the existing artificial (...) implementations. This scale offers both well defined levels of artificial consciousness and a method to calculate an orientative numerical score . A set of architectural and cognitive criteria is considered for each level of the scale. This permits the definition of a cognitive framework in which MC implementations can be ranked according to their potential capability to reproduce functional synergies associated with consciousness. The probability of the implementations having any phenomenal states related to the assessed functional synergy is not specifically addressed in this paper; nevertheless, it could be thoughtfully discussed elsewhere. (shrink)

En base a una confrontación estrictamente racional con la tradición filosófica, Plotino establece un principio transcendente al ser y al pensamiento y que, sin embargo, funge como principio creador, constitutivo y diferenciador de todo lo existente: el Uno o la Unidad absolutamente simple. En sí mismo inaccesible, se manifiesta ya sea por revelación (la cual sólo es una hipótesis para Plotino) o por sus efectos. Por eso, el discurso filosófico sobre el Uno sólo es posible desde la perspectiva de la (...) multiplicidad y, por tanto, tiene un carácter aproximativo. La forma que este discurso asume es necesariamente la de las vías analogiae, eminentiae y negationis. De este modo, la razón misma nos remite por primera vez a un principio que le antecede y que, a la vez la funda, dándose así inicio a una segunda época en la historia de la filosofía. (shrink)

I argue that from a very weak recombination principle and plausible assumptions about the nature of parthood and location it follows that it's possible that the mereological structure of the material world and that of spacetime fail to correspond to one another in very radical ways. I defend, moreover, that rejecting the possibility of such failures of correspondence leaves us with a choice of equally radical alternatives. I also discuss a few ways in which their possibility is relevant to various (...) debates in metaphysics. (shrink)

We study whether robots can satisfy the conditions of an agent fit to be held morally responsible, with a focus on autonomy and self-control. An analogy between robots and human groups enables us to modify arguments concerning collective responsibility for studying questions of robot responsibility. We employ Mele’s history-sensitive account of autonomy and responsibility to argue that even if robots were to have all the capacities required of moral agency, their history would deprive them from autonomy in a responsibility-undermining way. (...) We will also study whether humans and technological artifacts like robots can form hybrid collective agents that could be morally responsible for their actions and give an argument against such a possibility. (shrink)

I give shape to a neglected debate in metaphysics, the debate over the ontological priority between individuality and collectivity. I distinguish the debate from more familiar ones in the recent literature and articulate what I call ontological collectivism, the view that collectivity is prior to individuality. I defend the in-principle intelligibility of the view from forceful general objections and argue that not only is it coherent but also of significant interest to the literature: it allows for overlooked alternatives on a (...) variety of central discussions. (shrink)

This analysis comes from a philosophical glance at Aristophanic comedy, where the problem seems to move towards universality of poetry. The common manner to face this problem is getting close to the concepts of learning and inference, introduced in the field of a sort of action or a sort of character without consideration for the Aristotle’s horizon of the poetic research télos, érgon, oikeía hedone and katharsis, or the Greek theatrical-poetic representation as an autonomous form of universal mythos. The underestimation (...) of the comic genre has centered the research upon Aristophanes in the fields of politics, philology and history, but seldom philosophy. (shrink)

Various sources in the literature claim that the deduction theorem does not hold for normal modal or epistemic logic, whereas others present versions of the deduction theorem for several normal modal systems. It is shown here that the apparent problem arises from an objectionable notion of derivability from assumptions in an axiomatic system. When a traditional Hilbert-type system of axiomatic logic is generalized into a system for derivations from assumptions, the necessitation rule has to be modified in a way that (...) restricts its use to cases in which the premiss does not depend on assumptions. This restriction is entirely analogous to the restriction of the rule of universal generalization of first-order logic. A necessitation rule with this restriction permits a proof of the deduction theorem in its usual formulation. Other suggestions presented in the literature to deal with the problem are reviewed, and the present solution is argued to be preferable to the other alternatives. A contraction-and cut-free sequent calculus equivalent to the Hubert system for basic modal logic shows the standard failure argument untenable by proving the underivability of DA from A. (shrink)

This article examines the challenges surrounding the application of multicultural, outcomes-based curricula for teaching media ethics and communication ethics classes within a small journalism program. The main question to be answered here is: From the perspective of students, does it make a difference to employ a teaching model that is embedded in multicultural values, and rewards personal transformation and "measurable results"? An additional question is: From the perspective of instructors, how can we best assess student learning and personal growth in (...) fields as "subjective" and intangible as communication ethics and media ethics? (shrink)

The use of human language is a hallmark of human consciousness, even when it is not used publicly. Inner speech is the way humans consciously communicate with themselves and arguably a key factor contributing to the formation of more self-aware selves. From the perspective of cognitive science and artificial cognitive architectures, inner speech can be also seen as a meta-management system that modulates some cognitive processes of the subject. In this paper, we describe a preliminary version of a computational model (...) of inner speech generation based on the cognitive architecture CERA-CRANIUM. This inner speech generation method is illustrated using a video game non-player character as the subject of the first-person narratives to be produced. We also use this model of inner speech generation to discuss the possibilities of using such a first-person narrative stream as a meta-control input to the artificial cognitive architecture. We argue that this verbal input might be used as an integrated self-explanation of the agent in the world and thus contribute to the formation of self. (shrink)

This study aims at showing how at the basis of Nikolai Berdyaev’s criticism of capitalism and Marxism lays the concept of Imago Dei. The Russian religious philosopher puts forward the Imago Dei as fundamental to the Christian understanding of human dignity. Berdyaev believes that in both capitalism and Marxism an objectification of the person takes place, and therefore a denial of basic human dignity. Berdyaev’s criticism of capitalism refers to its internal principles, partly building on Marx’s early criticism of capitalism. (...) Although he shared some of the same concerns with Marx and other Marxist theorists, ultimately his was a critique from a Christian perspective that was deeply humanistic, whereas Marxism in its Hegelian orientation had failed in achieving what Berdyaev understands as true humanism. Having confronted and engaged both systems of thought during his own life, Berdyaev’s insights are most interesting, and I argue in this paper that they are also relevant for our own reflections on these subjects today. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2016 Heft: 208 Seiten: 133-154.

GIS has captured planning practice to an unprecedented degree, and this article on how it reconfigures and is configured by institutional context. The author inquires into GIS as a technology for incorporating knowledge into institutional use and includes five propositions: GIS's efficiencies in data processing allows it unprecedented facility and scope of analysis, its use increases alienation, its mimetic language furthers its role in planning, its logic appears rational—purposive, but it conceals an underlying normative logic, and its most profound effect (...) is on the mapper, and the alienating and normative character of GIS necessitate new modes of “social ground-truthing.” The author studies the southeast Los Angeles initiatives to demonstrate these propositions. This article compares two studies: one GIS-based, and the other based on participatory action research and discusses how GIS might be recontextualized into a technology for liberating democratizing processes. (shrink)

Endorsing the idea of group knowledge seems to entail the possibility of group belief as well, because it is usually held that knowledge entails belief. It is here studied whether it would be possible to grant that groups can have knowledge without being committed to the controversial view that groups can have beliefs. The answer is positive on the assumption that knowledge can be based on acceptance as well as belief. The distinction between belief and acceptance can be seen as (...) a refinement of the ordinary language concept of belief, and it may be useful in understanding the nature of epistemic justification and classifying various types of epistemic subjects. (shrink)

This reading companion and commentary on Lacan Seminar XXIII provides detailed analyses of Lacan's seminar while maintaining an overall continuity and consistency. This book does not purport to provide an exhaustive and systematic line-by-line reading of a very complex and varied seminar. Rather it selects key themes of Lacanian theory that are found present throughout his work. In addition, the book does not try to simplify Lacan's ambiguous style, leaving the text open to different interpretations, while providing theory, commentary, and (...) lines of analysis into some of Lacan's important insights. Finally, this book is not about Joyce the writer, but more about the use that Lacan makes of Joyce. Its purpose is not to apply psychoanalysis to a literary subject, but rather to use the literary text to illustrate and develop psychoanalytic theory, and Lacanian theory in particular. It is an analysis of topology and language, or a linguisterie, as Lacan called it, for clinicians. The references to neurosis and psychosis are always there. However, a Lacanian clinic can also be of service to those interested in literary theory and/or social studies to develop theory within their own respective fields of studies. (shrink)

"The Concept of Number", by Ernst Cassirer, is the second chapter of his first systematic work, the "Substanzbegriff und Funktionsbegriff: Untersuchungen über die Grundfragen der Erkenntniskritik", originally published in German in 1910. The translation to English, in 1953, by Marie Collins Swabeyand William Curtis Swabey, under the title "Substance and Function and Einstein's Theory of Relativity", despite its importance for having widely disseminated the work, loses in its title the work's essence: the opposition between "concept-substance" and "concept-function", or rather, between (...) "substantial-concept" and "functional-concept". Cassirer possesses along with a "theory of symbolical forms" a "theory of culture". These theories are "theories of conceptual formation" and they are in charge of various case studies developed by Cassirer in “Substanzbegriff und Funktionsbegriff”. Chapter 2, now translated, is a reading of the historical development of the concept of number under the view of a general theory of the concept that he presents in the second chapter of the book “Zur Theorie der Begriffsbildung” (On the theory of the conceptual formation). (shrink)

Epistemic justification of non-summative group beliefs is studied in this paper. Such group beliefs are understood to be voluntary acceptances, the justification of which differs from that of involuntary beliefs. It is argued that whereas epistemic evaluation of involuntary beliefs can be seen not to require reasons, justification of voluntary acceptance of a proposition as true requires that the agent, a group or an individual, can provide reasons for the accepted view. This basic idea is studied in relation to theories (...) of dialectical justification in which justification is taken to require ability to justify. Since the reasons offered can in principle always be challenged, there is no ultimate end to the dialectical chain of justification. This makes justification of acceptance, and thus group belief, social and, in a way, contextual, but this does not seem to entail strong forms of epistemic relativism. (shrink)

Esta investigación analiza la presencia del discurso eurocéntrico en los manuales de Historia del Arte de Bachillerato desde una dimensión sociogenética. La muestra se compone de ejemplares pertenecientes a editoriales españolas de alcance nacional (Anaya, ECIR, Ediciones Ruiz, SM, Teide y Vicens Vives) en una cronología que comprende los distintos periodos por los que ha atravesado la materia entre 1953 y 2006. El estudio deriva de la aplicación de un guion de análisis documental que contempla, entre sus variables, la construcción (...) de identidades. Los resultados muestran la presencia y resistencia sociohistórica del discurso eurocéntrico en los manuales de Historia del Arte analizados, tendiéndose con ello a la construcción, reproducción y esencialización de identidades etnocéntricas. De este modo, para ahondar en la formación de una ciudadanía crítica, se hace necesario replantear los enfoques y las finalidades que fundamentan el relato de la Historia del Arte escolar en recursos como el que nos ocupa en este trabajo. (shrink)

Se ofrece una interpretación del enfoque estructural, fenomenológico y ontológico del mito a partir de una productividad filosófica abierta en Ricoeur por ciertos elementos tomados de Kant, los cuales explican por qué el mito es analizado por la constitución de su forma, por su intención significativa y por su revelación ontológica.

Diversas investigaciones han mostrado que la tematización de la autoconciencia no es un exclusiva de la filosofía moderna. Plotino es tal vez el primero en haber reflexionado sobre las cuestiones fundamentales de una teoría de la autoconciencia y, ello, en confrontación con el escepticismo de Sexto Empírico. La autoconciencia es propia de la hipóstasis del nous como unidad diferenciada de Inteligencia, Inteligible e Intelección que, sin embargo, se constituye a sí misma en su vano intento de aprehender la Unidad absolutamente (...) simple del Uno. El artículo examina una reciente objeción a Plotino según la cual él se limitaría a describir en qué medida se puede reconstruir la Inteligencia como anterior a la relación, pero no resuelve la paradoja sobre la posibilidad de que de una relación resulte una identidad. (shrink)

Las cinco investigaciones que se incluyen en este libro se relacionan con la variacion lexica y conceptual de diferentes estratos sociales de Mexico. Sin duda, un mayor acervo conceptual de mayores posibilidades de comprender y modificar el mundo. A pesar de su importancia, este tipo de diferencias ha sido muy poco estudiado, mas especificamente, la semantica social puede considerarse como un campo nuevo en la linguistica. Mexico es un pais con diferencias economicas bastante notables, y los intereses de la gente (...) se relacionan con este hecho. Mientras unos se preocupan por la educacion y la cultura, los valores y las ideas, otros piensan fundamentalmente en el alimento y en el vestido. Las diferencias que encuentra el autor lo llevan a proponer que, en Mexico al parecer, la riqueza lexica y conceptual esta tan mal distribuida como la economica. (shrink)